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After the disaster with the T-Virus, the Umbrella Corp. decided to make a second virus known as the Q4-Virus. But tests shown that when the T-Virus and the Q4-Virus mixed, it caused dangerous mutations. Tempted with their evil minds the Umbrella Corp. decided to inject both the T-Virus and the Q4-Virus into a human host. The effect was beyond what the tests had shown and a new infection has been created. The infection took over Racoon City and then went for SkyLight City. The infection spread through the city within twelve hours leaving but a few survivors.