So I used the cheat to get the pimp slap hand because I heard you can't get it in-game any other way and after having a little rampage with it I put it away, the entertainment value wearing off. Then I saved, completely overlooking the warning about cheats and after I realised this may in fact be bad.

So are there any downside to having cheats active (PS3 version, btw, so there won't be any achievement blockage xD), like perhaps having a different ending or blocking certain things? And is there any way to deactivate the pimp slap hand as a cheat? Thanks.

If you're playing the 360 version it blocks achievements ('cause having infinite health comes in handy for things like surviving with full notoriety and whatnot). If the PS3 version had trophies it would do the same, but it doesn't

Thanks for the answers.