I cannot kill the mayor in the first town. I've got my armor up and have done everything else.

Any ideas?

ummm, watch for the blinking grenades he throws, they do quite a bit of splash damage that early in the game, just shoot him with a gun of any sort, or, like i did it, run up to him when he stops throwing grenades and whack him twice or three times until he starts throwing grenades again, then run around him in large circles as he throws grenades (killing off or damaging any townspeople trying to kill you) then when he stops go whack him some more...

easier, just aim a gun at him and shoot him as you strafe in circles around him....

Thanks for the response!