Generally this comes down to speed vs power, and normally red9 vs Blacktail, though there are supporters of the other two out there personally i prefer the RED9, the power of it with exclusive is great and with the stock it can be used from close to long range, good for conserving rifle ammo for the long, to Xlong range shots and pistol it conserves pistol ammo because og its high fire power.

quote Maser

In general, the Blacktail is best. The Handgun is VERY handy on the island. The Red9 is only cool with the stock. As for the Punisher, I find it totally useless except for use on shielded enemies.

Yeah the punisher is good against shielded enemies but then the RED9 is powerful enough to break the shield and the kill them and the black tail shoots fast enough to break through the shielf and then kill them.