Every time I reach a certain point in the game the game crashes to the desktop. When I use the patch there's first the loading screen but then nothing happens and I remain at the desktop.
Does anyone have a solution or the same problem?

Very mild spoilers may be ahead.

I had a similar problem. I have an Athlon 1700+, 768M DDR, Radeon 8500 BBA w/128M, SB Live, win2000 sp4 with the compatibility tab (slayerui.dll) activated, Soul Reaver full install 1.2 unofficial XP patch. I set the shortcut to be win95 compatible, and it seemed to work just fine.

However, when I reached a certain point in the game it crashed, always at the exact same point. I noticed that this was after reloading a saved game, so I downloaded a different savegame, and it did not crash. But of course I did not want a savegame with all the bosses killed and all the puzzles solved.

What seems to work for me is to only save in the starting room. It's a bit awkward, but if you do the following, you just might get lucky and be able to reload your savegames without crashes;

When you want to save, switch to the spectral realm and get yourself killed (yes, really), you will be transported back to the starting room. Just for good measure I wait until my energy bar fills up, and then save. This may sound a little silly, but when you reload your game you will be in the starting room anyway, so this is no great loss. I can't promise that this really works, but so far I'm in the Cathedral with no crashes, whereas before it always crashed well before I even reached Melchia.

Hopefully this will help somebody.